Fawaz G. Haj, Ph.D.

Fawz Haj

Professor and Vice Chair, Department of Nutrition
Professor, Department of Internal Medicine
Nutritionist in Agricultural Experiment Station

3115 Meyer Hall | Lab: 4306 Meyer Hall
  • B.Sc., Biology, American University of Beirut
  • M.Sc., Biomedical Sciences, Bradford University
  • D.Phil., Physiology, Oxford University
Research Interests

Dr. Haj's laboratory studies the molecular basis of metabolic diseases, mainly obesity and type 2 diabetes. In particular, we are interested in the role of tyrosine phosphorylation and how dysregulation of this key signaling mechanism contributes to metabolic diseases and their complications. We investigate the role of protein-tyrosine phosphatases and their interacting partners in metabolic homeostasis. This is achieved using a combination of genetic, biochemical, proteomic and pharmacological approaches in various experimental platforms (cells, rodent models of disease and humans).

Lab: http://hajlab.ucdavis.edu

Post Graduate Training
  • Postdoctoral Fellow, Harvard Medical School
  • Instructor in Medicine, Harvard Medical School
  • Visiting Scientist, European Molecular Biology Laboratory
Academic Appointments
  • Assistant Professor, Nutrition Department, University of California Davis, 2007-2011
  • Associate Professor, Nutrition Department, University of California Davis, 2011-2015
  • Associate Professor, Internal Medicine Department, University of California Davis, 2012-2015
  • Professor, Nutrition Department, University of California Davis, 2015-present
  • Professor, Internal Medicine Department, University of California Davis, 2015-present
Administrative Appointments
  • Director, Meyer Hall Animal Facility, University of California Davis, 2008-present
  • Co-Director, Metabolism and Endocrinology Core, National Mouse Metabolic Phenotyping Center, University of California Davis, 2011-present
Awards and Honors
  • Oxford University, Oxford Overseas Bursaries, 1997
  • Oxford University, Overseas Research Scholarship, 1997
  • Harvard University, Certificate of Excellence in Research, 2001
  • American Diabetes Association Junior Faculty Award, 2006
  • University of California Davis, Hellman Fellow, 2008
Oral Presentations
  • Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miami, Florida, USA
  • School of Medicine, University of Miami, Miami, Florida, USA
  • Pre-Obesity Society Symposium, Orlando, Florida, USA
  • 9th International Conference on Protein Phosphatases, Tokyo, Japan
  • Department of Microbiology, Yokohama City University, Yokohama, Japan
  • EMBO conference on protein phosphatases, Vienna, Austria
  • Department of Biology, University of Copenhagen, Copenhagen, Denmark
  • Frontiers of Science, Engineering and Medicine Symposium, Kuwait Institute for Scientific Research, Kuwait City, Kuwait
  • Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
  • Taiwan Society for Biochemistry and Molecular Biology, Taipei, Taiwan
  • Department of Biological Sciences, National University of Singapore, Singapore
  • Duke-National University of Singapore Graduate Medical School, Singapore
  • Comprehensive Cancer Center, University of California Davis, Sacramento, CA, USA
  • Department of Orthopedics, University of California Davis, Sacramento, CA, USA
  • Protein Phosphatases Conference, Silvertree, CO, USA
  • Department of Nutritional Biology and Toxicology, University of California Berkeley, CA, USA
  • Phosphatases in human disease conference, Melbourne, Australia
  • Garvan Institute, Sydney, Australia
  • International conference on obesity and weight management, Philadelphia, PA, USA
  • Royal Society Metabolism and Endocrinology Themed Meeting, London, UK.
  • Division of Endocrinology, Diabetes and Metabolism, University of California Davis, Sacramento, CA
  • 10th International Conference on Protein Phosphatases and Diseases, Tokyo, Japan
  • Brain-Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Japan
  • Nutrition, Oxygen Biology and Medicine Conference, Paris, France
  • Department of Molecular Cell Biology, University of Leuven, Belgium
  • VI International Conference on Polyphenols and Health, Buenos Aires, Argentina
  • Institute of Biomedical Investigation Alberto Sols, Madrid, Spain
  • Department of Physiology, University of Valencia, Valencia, Spain
  • Biotechnology Research Institute, University of San Martin, Buenos Aires, Argentina
  • MRC Clinical Sciences Centre, Imperial College, London, UK
  • Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University, Oxford, UK
  • 17 th Biennial Meeting of Society for Free Radical Research International, Kyoto, Japan
  • Foods For Health Institute, University of California Davis, Davis, CA, USA
  • Comprehensive Cancer Center, University of California Davis, Sacramento, CA, USA
  • FASEB conference on Protein Phosphatases, Nassau, Bahamas
  • 11th International Conference on Protein Phosphatases, Sendai, Japan
Selected Publications

Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 1;27(5):1156. [PubMed]

Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza PI.  (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018 Apr;14:588-599. [PubMed]

Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG.  Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J. 2017 Jul;284(13):1970-1986. May 29. Erratum in: FEBS J. 2018 Feb;285(3):629-632. [PubMed]

Warden CH, Bettaieb A, Min E, Fisler JS, Haj FG, Stern JS. Chow fed UC Davis strain female Lepr fatty Zucker rats exhibit mild glucose intolerance, hypertriglyceridemia, and increased urine volume, all reduced by a Brown Norway strain chromosome 1 congenic donor region. PLoS One. 2017 Dec 6;12 (12):e0188175. [PubMed]

Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochim Biophys Acta. 2017 Nov;1861(11 Pt A):2758-2765. [PubMed]

Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD.  Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 2017 Nov;133:68-78. [PubMed]

Ito Y, Hsu MF, Bettaieb A, Koike S, Mello A, Calvo-Rubio M, Villalba JM, Haj FG. Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism. 2017 Nov;76:56-69. [PubMed]

Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA.A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 5;26(3):539-546.e5. [PubMed]

Bailey KA, Haj FG, Simon SI, Passerini AG.  Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. Sci Rep. 2017 Aug 15;7(1):8196. [PubMed]

Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis. J Pharmacol Exp Ther. 2017 Jun;361(3):408-416. [PubMed]

Hsu MF, Bettaieb A, Ito Y, Graham J, Havel PJ, Haj FG. Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep. 2017 Mar 28;7(1):461. [PubMed]

Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016 Aug 31. pii: S1357-2725(16)30261-8. [PubMed]

Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD, Haj FG, Meng TC. S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling. Free Radic Biol Med. 2016 Aug 10;99:199-213. [PubMed]

Bettaieb A, Koike S, Chahed S, Bachaalany S, Griffey S, Sastre J, Haj FG. Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice. Am J Pathol. 2016 Aug;186(8):2043-54. [PubMed]

Cremonini E, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys. 2016 Jun 1;599:13-21. [PubMed]

McGavigan AK, Garibay D, Henseler ZM, Chen J, Bettaieb A, Haj FG, Ley RE, Chouinard ML, Cummings BP. TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut. 2015 Oct 28. pii: gutjnl-2015-309871. [PubMed]

Bettaieb A, Hosein E, Chahed S, Abdulaziz A, Kucera HR, Gaikwad NW, Haj FG. Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity (Silver Spring). 2015 Sep 16. doi: 10.1002/oby.21263. [PubMed]

Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. [PubMed]

Bettaieb A, Chahed S, Bachaalany S, Griffey S, Hammock BD, Haj FG. Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice. Mol Pharmacol. 2015 Aug;88(2):281-90. [PubMed]

Jialal I, Devaraj S, Bettaieb A, Haj F, Adams-Huet B. Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome.  Atherosclerosis. 2015 Jul;241(1):130-7. [PubMed]

Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ. Hepatocyte NADPH Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015 Apr 14. pii: S0016-5085(15)00509-0.  [PubMed]

Vazquez Prieto MA, Bettaieb A, Rodriguez Lanzi C, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza PI. Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes. Mol Nutr Food Res. 2015 Apr;59(4):622-33. [PubMed]

Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.  Toxicol Appl Pharmacol. 2015 Mar 28. pii: S0041-008X(15)00113-1. [PubMed]

Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E, Chahed S, Wiede F, Zhang S, et al. Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia. 2015 Jan;58:122-31. [PubMed]

Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PloS one. 2014;9:e113019. [PubMed]

Prieto MA, Bettaieb A, Lanzi CR, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza PI. Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and in 3T3-L1 adipocytes. Molecular nutrition & food research. 2015 Jan 24. [PubMed]

Bakke J, Haj FG. Protein-tyrosine phosphatase 1B substrates and metabolic regulation. Seminars in cell & developmental biology. 2015 Jan;37C:58-65. [PubMed]

Borkowski K, Wrzesinski K, Rogowska-Wrzesinska A, Audouze K, Bakke J, Petersen RK, Haj FG, Madsen L, Kristiansen K. Proteomic analysis of cAMP-mediated signaling during differentiation of 3 T3-L1 preadipocytes. Biochimica et biophysica acta. 2014 Aug 22;1844:2096-107. [PubMed]

Siming Liu, Yannan Xi, Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Rohit Kulkarni and Fawaz Haj (2014). Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology. Sep;155(9):3329-38. [PubMed]

Ahmed Bettaieb, Marcela Vazquez Prieto, Cecilia Rodriguez Lanzi, Roberto Miatello, Fawaz Haj, Cesar Fraga and Patricia Oteiza (2014). (−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radical Biology and Medicine, 72C:247-256. [PubMed]

Even Fjære, Ulrike Aune, Kristin Røen, Alison Keenan, Tao Ma, Kamil Borkowsky, David Kristensen, Guy Novotny, Thomas Mandrup-Poulsen, Brian Hudson, Graeme Milligan, Yannan Xi, John Newman, Fawaz Haj, Bjørn Liaset, Karsten Kristiansen and Lise Madsen (2014). Indomethacin treatment prevents high-fat diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice. Journal of Biological Chemistry, (23):16032-45. [PubMed]

Bethany Cummings, Ahmed Bettaieb, James Graham, Kimber Stanhope, Fawaz Haj and Peter Havel (2014). Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats. Journal of Endocrinology, 221(1):133-44. [PubMed]

Ahmed Bettaieb, Yannan Xi, Ellen Hosein, Nicole Coggins, Santa Bachaalany, Florin Wiede, Salvador Perez, Stephen Griffey, Juan Sastre, Tony Tiganis and Fawaz Haj (2014). Pancreatic T cell Protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Communication and Signaling, 12:13. [PubMed]

Craig Warden, Carolyn Slupsky, Stephen Griffey, Ahmed Bettaieb, Esther  Min, Anh Le, Janis Fisler, Susan Hansen, Fawaz Haj, Judith Stern (2014). Brown Norway chromosome 1 congenic reduces symptoms of renal disease in fatty Zucker rats. PLoS One, 9(1):e87770. [PubMed]

Wang YI, Bettaieb A, Sun C, DeVerse JS, Radecke CE, Mathew S, Edwards CM, Haj FG, Passerini AG, Simon SI. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One. 2014 Jan 31;9(1):e87770. [PubMed]

Bakke J, Bettaieb A, Nagata N, Matsuo K, Haj FG. Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B. Cell Commun Signal. 2013 Aug 12;11:57.  [PubMed]

Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. J Biol Chem. 2013 Jun 14;288(24):17360-71. [PubMed]

Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem. 2013 May 17;288(20):14189-99. [PubMed]

Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH.Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1175-87. [PubMed]

Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech. 2013 Mar;6(2):443-56. [PubMed]

Bora Inceoglu, Karen Wagner, Jun Yang, Ahmed Bettaieb, Nils Schebb, Fawaz Haj, Bruce Hammock (2012). Augmentation of epoxygenated fatty acid levels rapidly reduce pain-related behavior without significantly altering acute glucose metabolism in a rat model of type I diabetes. Proceedings of the National Academy of Sciences, Jul 10;109(28):11390-5. [PubMed]

Bethany Cummings, Ahmed Bettaieb, James Graham, Kimber Stanhope, Mark Kowala, Fawaz Haj, Michael Chouinard, and Peter Havel (2012). Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology, Aug;153(8):3620-32. [PubMed]

Naoto Nagata, Kosuke Matsuo, Ahmed Bettaieb, Jesse Bakke, Izumi Matsuo, James Graham, Yannan Xi, Siming Liu, Alexey Tomilov, Natalia Tomilova, Susan Gray, Dae Young Jung, Jon Ramsey, Jason Kim, Gino Cortopassi, Peter Havel and Fawaz Haj (2012). Hepatic Src Homology Phosphatase 2 regulates energy balance in mice. Endocrinology, Jul;153(7):3158-69. [PubMed]

Fawaz Haj, Ola Sabet, Ali Kinkhabwala, Sabine Wimmer-Kleikamp, Vassilis Roukos,Hong-Mei Han, Markus Grabenbauer, Martin Bierbaum, Claude Antony, Benjamin Neel, and Philippe Bastiaens (2012). Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B. PLoS One, 7(5):e36633. [PubMed]

Ahmed Bettaieb, Kosuke Matsuo, Shuo Wang, Izumi Matsuo, Ramzi Melhem, Antonis Koromilas and Fawaz Haj (2012). Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes. PLoS One, 7(4):e34412. [PubMed]

Marcela Vazquez Prieto, Ahmed Bettaieb, Fawaz Haj, Cesar Fraga, Patricia Oteiza (2012). (-)-Epicatechin prevents TNFα-induced activation of signaling cascades leading to inflammation and insulin resistance in 3T3 adipocytes. Archives of Biochemistry and Biophysics, Nov 15; 527(2):113-8. [PubMed]

Bethany Cummings, Ahmed Bettaieb, James Graham, Kimber Stanhope, Riva Dill, Gregory Morton, Fawaz Haj and Peter Havel (2011). Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetes UCD-T2DM rats. Proceedings of the National Academy of Sciences, August 30; 108(35):14670-5.  [PubMed]

Ayala Luria, Ahmed Bettaieb, Yannan Xi, Guang-Jong Shieh, Hsin-Chen Liu, Hiromi Inoue, Hsing-Ju Tsai, John Imig, Fawaz Haj and Bruce Hammock (2011). Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance induced by high fat diet. Proceedings of the National Academy of Sciences, May 31;108(22):9038-43. [PubMed]

Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo and Fawaz Haj (2011). Adipose-specific Src Homology Phosphatase 2 deficiency does not significantly alter systemic glucose homeostasis. Metabolism, Aug;60(8):1193-201.  [PubMed]

Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo and Fawaz Haj (2011). Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. PLoS One, Jan 31;6(1):e16446. [PubMed]

Ahmed Bettaieb, Siming Liu, Yannan Xi, Naoto Nagata, Kosuke Matsuo, Izumi Matsuo, Samah Chahed, Jesse Bakke, Heike Keilhack, Tony Tiganis and Fawaz Haj (2011). Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. Journal of Biological Chemistry, Mar 18;286(11):9225-35.  [PubMed]

Eva Nievergall, Peter Janes, Carolin Stegmayer, Mary Vail, Fawaz Haj, Shyh Wei Teng, Benajmin Neel, Philippe Bastiaens and Martin Lackman (2010). Protein-Tyrosine Phosphatase 1B regulates Eph receptor function and trafficking. Journal of Cell Biology, Dec 13; 191(6):1189-203. [PubMed]

Kosuke Matsuo, Mirela Delibegovic, Izumi Matsuo, Naoto Nagata, Siming Liu, Ahmed Bettaieb, Yannan Xi, Kazu Araki, Wentien Yang, Barbara Kahn, Benjamin Neel and Fawaz Haj (2010). Altered glucose homeostasis in mice with liver-specific deletion of Src Homology Phosphatase 2. Journal of Biological Chemistry, Dec 17, 285(51):39750-8. [PubMed]

Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB (2009). Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol. Aug;29(16):4563-73. [PubMed]

Shrikrishna Dadke, Sophie Cotteret, Shu-Chin Yip, Zahara Jaffer, Fawaz Haj, Alexey Ivanov, Frank Rauscher III, Ke Shuai, Tony Ng, Benjamin Neel, and Jonathan Chernoff (2007).  Regulation of protein-tyrosine phosphatase 1B through sumoylation.  Nature Cell Biology.  Jan, 9(1): 80-85. [PubMed]

Elena Arias-Salgado, Fawaz Haj, Christophe Dubois, Barry Moran, Ana Kasirer-Friede, Barbara Furie, Bruce Furie, Benjamin Neel and Sanford Shattil (2005).  PTP-1B is an essential positive regulator of platelet integrin signaling.  Journal of Cell Biology.  Aug 29,170 (5): 837-45. [PubMed]

Fawaz Haj, Janice Zabolotny, Young-Bum Kim, Barbara Kahn and Benjamin Neel (2005).  Liver-specific re-expression of protein-tyrosine phosphatase 1B reverses insulin sensitivity in PTP1B knockout mice.  Journal of Biological Chemistry.  Apr 15, 280 (15): 15038-46. [PubMed]

Sandra Galic, Christine Hauser, Barbara Kahn, Fawaz Haj, Benjamin Neel, Nicholas Tonks, and Tony Tiganis (2005).  Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.  Molecular and Cellular Biology.  Jan, 25 (2): 819-29. [PubMed]

Janice Zabolotny, Fawaz Haj, Jason Kim, Young-Bum Kim, Gerald Shulman, Barbara Kahn and Benjamin Neel (2004).  Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.  Journal of Biological Chemistry.  Jun 4, 279 (23): 24844-51. [PubMed]

Camilla Persson, Catrine Svenhed, Annie Bourdeau, Michel Tremblay, Boyka Markova, Frank Bhmer, Fawaz Haj, Benjamin Neel, Carl-Henrik Heldin, Lars Rnnstrand, Arne stman and Carina Hellberg (2004).  Site-selective regulation of platelet growth factor b receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.  Molecular and Cellular Biology.  Mar 1, 24 (5): 2190-2201. [PubMed]

Jake Kushner, Fawaz Haj, Lori Klaman, Mathew Dow, Barbara Kahn, Benjamin Neel and Morris White (2004).  Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.  Diabetes.  Jan, 53 (1): 61-66.[PubMed]

Gustavo Sajnani-Perez, John Chilton, Radu Aricescu, Fawaz Haj, Andrew Stoker (2003).  Isoform-specific binding of the tyrosine phosphatase PTPs to a ligand in developing muscle.  Molecular and Cellular Neuroscience.  Jan, 22 (1): 37-48. [PubMed]

Fawaz Haj, Boyka Markova, Lori Klaman, Frank Bohmer and Benjamin Neel (2003).  Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.  Journal of Biological Chemistry.  Jan 10, 278 (2): 739-44. [PubMed]

Janice Zabolotny, Kendra Bence, Alain Stricker-Krongrad, Fawaz Haj, Young-Ping Wang, Yasuhiko Minokoshi, Young-Bum Kim, Joel Elmquist, Luois Tartaglia, Barbara Kahn, Benjamin Neel (2002).  PTP1B regulates leptin signal transduction in vivo.  Developmental Cell.  Apr, 2 (4): 489-95. [PubMed]

Fawaz Haj, Peter Verveer, Anthony Squire, Benjamin Neel and Philippe Bastiaens (2002).  Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum.  Science.  Mar, 295 (5560): 1708-11. [PubMed]

Matthias Ledig, Fawaz Haj, John Bixby, Andrew Stoker and Bernhard Mueller (1999).  The receptor protein tyrosine phosphatase CRYPa promotes intraretinal axon growth.  Journal of Cell Biology.  Oct, 147 (2): 375-88. [PubMed]

Fawaz Haj, Iain Mckinnell and Andrew Stoker (1999).  Retinotectal ligands for the receptor tyrosine phosphatase CRYPa.  Molecular and Cellular Neuroscience.  Sep, 14 (3): 225-40. [PubMed]

Andrew Stoker, Bernhard Gehrig, Fawaz Haj and Boon-Huat Bay (1995).  Axonal localization of the CAM-like tyrosine phosphatase CRYPa: a signaling molecule of embryonic growth cones.  Development.  Jun, 121 (6): 1833-44. [PubMed]