Hagen Schroeter, Ph.D.

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Position Title
Research Associate
Director Biomedical Research/Fundamental Cocoa Flavanol Research, MARS, Incorporated

3150B Meyer Hall
  • B.Sc., Biochemistry, University of Leipzig, Institute of Biochemistry
  • M.Sc., Biochemistry, University of Leipzig, Institute of Biochemistry
  • Ph.D., Biochemistry, King’s College London
Research Interests

Dr. Schroeter’s main research interests focus on the elucidation of the molecular and cellular mechanisms underlying the putative beneficial effects of flavanols against degenerative human diseases such as cardiovascular disorders and neurodegeneration. In this context, Dr. Schroeter investigates the relationship between physiological/pathophysiological cellular stimuli, MAPK/PI-3-kinase signaling and a particular biological response with regard to apoptosis, survival and adaptation.

Current research projects include:

  1. Investigations into the potential flavan-3-ol/proanthocyanidin-mediated modulation of endothelial nitric oxide synthesis in vivo and in vitro.
  2. The study of the endothelial glycocalyx with regard to cellular uptake of flavan-3-ols/proanthocyanidins and the effects this may have on the mobility within different pharmacological compartments in vivo.
  3. The analysis of flavan-3-ol biotransformation/metabolism in humans and animals with regard to pharmacokinetic parameters as well as tissue distribution/concentration using radiolabeled tracers.
Selected Publications

Ottaviani JI, Borges G, Momma TY, Spencer JP, Keen CL, Crozier A, Schroeter H. The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives. Sci Rep. 2016 Jul 1;6:29034. [Pubmed]

Ottaviani JI, Balz M, Kimball J, Ensunsa JL, Fong R, Momma TY, Kwik-Uribe C, Schroeter H, Keen CL. Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial. Am J Clin Nutr. 2015 Nov 4. pii: ajcn116178. [PubMed]

Schroeter H, Keen CL, Sesso HD, Manson JE, Lupton JR. Is this the end of (-)-epicatechin, or not? New study highlights the complex challenges associated with research into the cardiovascular health benefits of bioactive food constituents. Am J Clin Nutr. 2015 Oct;102(4):975-6. doi: 10.3945/ajcn.115.117283. [PubMed]

Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL: The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radicals in Biology and Medicine; 2010, November, in press; [PubMed]

Schroeter H, Heiss C, Spencer JP, Keen CL, Lupton JR, Schmitz HH: Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs. Molecular Aspects of Medicine; 2010, September 18. [Epub ahead of print]; [PubMed]

Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y.; Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. Journal of the American College of Cardiology; 2010 Jul 13;56(3):218-24. [PubMed]

Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross H, Keen CL, Schroeter H, Kelm M; Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients: A double-masked, randomized, controlled trial. Journal of the American College of Cardiology; 2008 Jun 3;51(22):2141-9. [PubMed]

van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage FH. (2007) Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. Journal of Neuroscience 30;27(22):5869-78. [PubMed]

Schroeter H, Bahia P, Spencer JP, Sheppard O, Rattray M, Cadenas E, Rice-Evans C, Williams RJ. (2007) (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry. 101(6):1596-606. [PubMed]

H. Schroeter, C. Heiss, J. Balzer, P. Kleinbongard, C.L. Keen, N.K. Hollenberg, H. Sies, C. Kwik-Uribe, H.H. Schmitz and M. Kelm (2006) Flavanols, epicatechin, and vascular function: An insight into the health benefits of diets rich in fruit and vegetables. Proceedings of the National Academy of Sciences of the USA; 24;103(4):1024-9.

C. Heiss, P. Kleinbongard, A. Dejam, S. Perre’, H. Schroeter, H. Sies and M. Kelm (2005) Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. Journal of the American College of Cardiology 46(7):1276-1283. [PubMed]

H. Schroeter, R.R. Holt, TJ Orozco, H.H. Schmitz, C.L. Keen (2003) Nutrition: Milk and the absorption of dietary flavanols. Nature 426(6968):787-788. [PubMed]