Patricia I. Oteiza, Ph.D.

Education

• M.S., Clinical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
• M.S., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
• Ph.D., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

Research Interests

Dr. Oteiza has two primary areas of research. The first is centered on the characterization of the effects of trace mineral deficiencies and trace mineral toxicities on early developmental processes. Dr. Oteiza’s second area of research is focused on the putative health benefits of flavonoids.

Selected Publications

Rodriguez Lanzi C, Perdicaro DJ, Landa MS, Fontana A, Antoniolli A, Miatello RM, Oteiza PI, Vazquez Prieto MA. Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. J Nutr Biochem. 2018 Jun;56:224-233. [PubMed]

Cremonini E, Oteiza PI. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells. Arch Biochem Biophys. 2018 May 15;646:55-63. [PubMed]

Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza PI.  (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018 Apr;14:588-599. [PubMed]

Fraga CG, Oteiza PI, Galleano M. Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm. Mol Aspects Med. 2018 Feb 10. pii: S0098-2997(18)30002-5. [PubMed]

Oteiza PI, Fraga CG, Mills DA, Taft DH. Flavonoids and the gastrointestinal tract: Local and systemic effects. Mol Aspects Med. 2018 Jan 12. pii: S0098-2997(17)30159-0. [PubMed]

Cremonini E, Mastaloudis A, Hester SN, Verstraeten SV, Anderson M, Wood SM, Waterhouse AL, Fraga CG, Oteiza PI. Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Food Funct. 2017 Aug 1;8(8):2915-2923. [PubMed]

Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016 Aug 31. pii: S1357-2725(16)30261-8. [PubMed]

Cremonini E, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys. 2016 Jun 1;599:13-21. [PubMed]

Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza PI. The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 Jan 15. [PubMed]

Huang YL, Supasai S, Kucera H, Gaikwad NW, Adamo AM, Mathieu P, Oteiza PI. Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation. Food Funct. 2015 Dec 8. [PubMed]

Prince PD, Lanzi CR, Toblli JE, Elesgaray R, Oteiza PI, Fraga CG, Galleano M.  Dietary (-)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats. Free Radic Biol Med. 2015 Nov 10;90:35-46.   [PubMed]

Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza PI. Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway. J Nutr Biochem. 2015 Jun 9. [PubMed]

Prieto MA, Bettaieb A, Lanzi CR, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza PI. Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and in 3T3-L1 adipocytes. Molecular nutrition & food research. 2015 Jan 24. [PubMed]

Verstraeten SV, Fraga CG, Oteiza PI. Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance. Food & function. 2015 Jan;6:32-41. [PubMed]

Bettaieb A, Vazquez Prieto MA, Rodriguez Lanzi C, Miatello RM, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free radical biology & medicine. 2014 Jul;72:247-56. [PubMed]

Queisser N, Oteiza PI, Link S, Hey V, Stopper H, Schupp N. Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxidants & redox signaling. 2014 Nov 20;21:2126-42. [PubMed]

Nuttall JR, Oteiza PI. Zinc and the aging brain. Genes & nutrition. 2014 Jan;9:379. [PubMed]

Verstraeten SV, Jaggers GK, Fraga CG, Oteiza PI. Procyanidins can interact with Caco-2 cell membrane lipid rafts: Involvement of cholesterol. Biochimica et biophysica acta 2013;1828(11):2646-53. [PubMed]

Omata Y, Salvador GA, Supasai S, Keenan AH, Oteiza PI. Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicological sciences : an official journal of the Society of Toxicology 2013;133(1):90-100. [PubMed]

Fraga CG, Oteiza PI, Galleano M. In vitro measurements and interpretation of total antioxidant capacity. Biochimica et biophysica acta 2013. [PubMed]

Choy YY, Jaggers GK, Oteiza PI, Waterhouse AL. Bioavailability of intact proanthocyanidins in the rat colon after ingestion of grape seed extract. Journal of agricultural and food chemistry 2013;61(1):121-7. [PubMed]

Biasi F, Leonarduzzi G, Oteiza PI, Poli G. Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets. Antioxidants & redox signaling 2013. [PubMed]

Vazquez-Prieto MA, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Archives of biochemistry and biophysics 2012;527(2):113-8. [PubMed]

Oteiza PI. Zinc and the modulation of redox homeostasis. Free radical biology & medicine 2012;53(9):1748-59. [PubMed]

Nuttall JR, Oteiza PI. Zinc and the ERK kinases in the developing brain. Neurotoxicity research 2012;21(1):128-41. [PubMed]

Litterio MC, Jaggers G, Sagdicoglu Celep G, Adamo AM, Costa MA, Oteiza PI, Fraga CG, Galleano M. Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels. Free radical biology & medicine 2012;53(10):1894-902. [PubMed]

Galleano M, Calabro V, Prince PD, Litterio MC, Piotrkowski B, Vazquez-Prieto MA, Miatello RM, Oteiza PI, Fraga CG. Flavonoids and metabolic syndrome. Annals of the New York Academy of Sciences 2012;1259:87-94. [PubMed]

Forester SC, Choy YY, Waterhouse AL, Oteiza PI. The anthocyanin metabolites gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro-oncogenic signals. Molecular carcinogenesis 2012. [PubMed]

Da Silva M, Jaggers GK, Verstraeten SV, Erlejman AG, Fraga CG, Oteiza PI. Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells. Free radical biology & medicine 2012;52(1):151-9. [PubMed]

Salvador GA, Oteiza PI. Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells. Neurotoxicology 2011;32(1):75-82. [PubMed]

Queisser N, Schupp N, Stopper H, Schinzel R, Oteiza PI. Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase. Free radical biology & medicine 2011;51(11):1996-2006. [PubMed]

Queisser N, Oteiza PI, Stopper H, Oli RG, Schupp N. Aldosterone induces oxidative stress, oxidative DNA damage and NF-kappaB-activation in kidney tubule cells. Molecular carcinogenesis 2011;50(2):123-35. [PubMed]

Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free radical biology & medicine 2011;51(2):480-9. [PubMed]

Fraga CG, Oteiza PI. Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. Free radical biology & medicine 2011;51(4):813-23. [PubMed]

Verstraeten SV, Mackenzie GG, Oteiza PI. The plasma membrane plays a central role in cells response to mechanical stress. Biochimica et biophysica acta 2010;1798(9):1739-49. [PubMed]

Oteiza PI. Trace elements in physiology and pathology. BioFactors (Oxford, England) 2010;36(2):87. [PubMed]

Galleano M, Verstraeten SV, Oteiza PI, Fraga CG. Antioxidant actions of flavonoids: thermodynamic and kinetic analysis. Archives of biochemistry and biophysics 2010;501(1):23-30. [PubMed]

Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. Basic biochemical mechanisms behind the health benefits of polyphenols. Molecular aspects of medicine 2010;31(6):435-45. [PubMed]

Aimo L, Cherr GN, Oteiza PI. Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation. Free radical biology & medicine 2010;48(12):1577-87. [PubMed]

Aimo, L., Mackenzie, G. G., Keenan, A. , and Oteiza, P. I.  Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-kB and NFAT in fetal brain. J. Nut. Biochem. 2010;21(11):1069-75. [PubMed]

Adamo, A. M. and Oteiza, P. I. Zinc deficiency and neuronal development. Biofactors. Mar;36(2):117-24. (2010) [PubMed]

Adamo, A. M.,  Zago, M. P, Mackenzie, G.G., Aimo, L., Keen, C. L.,  Keenan, A. and Oteiza, P. I. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotoxicology Research 17:1-14 (2010). [PubMed]

Galleano, M., Oteiza P.I. and Fraga C.G. Cocoa, chocolate and cardiovascular disease. Journal of Cardiovascular Pharmacology. 54:483-490  (2009). [PubMed]

Mackenzie, G. G., Delfino, J.M., Keen, C.L., Fraga, C.G. and Oteiza, P. I.  Dimeric procyanidins are inhibitors of NFkappaB-DNA binding.  Biochemical. Pharmacology 78:1252-1262 (2009). [PubMed]

Mackenzie, G. G. and Oteiza, P. I.  Zinc and the cytoskeleton in neuronal signaling. In  Micronutrients and Brain Health, edited by Lester Packer, Helmut Sies, Manfred Eggersdorfer and Enrique Cadenas. CRC Press, pp. 149-161 (2009).

Verstraeten, S., Oteiza, P. I and Fraga, C. G. (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells.  Free Radical Research  42:864-872 (2008). [PubMed]

Verstraeten, S., Aimo, L. and Oteiza, P. I.  Aluminium and lead: molecular mechanisms of brain toxicity. Archives of Toxicology 82:789-802. (2008). [PubMed]

Erlejman, A. G., Jaggers, G., Fraga, C. G., and Oteiza, P. I. TNFα-induced NF-κB activation and cell oxidant production is modulated by hexameric procyanidins in Caco-2 cells. Archives of Biochemistry and Biophysics 476:186-195 (2008). [PubMed]

Mackenzie, G. G., Queiser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M., and Oteiza, P. I.  Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kB and STAT3 pathways in Hodgkin’s lymphoma cells.  International Journal of Cancer 123:56-65 (2008). [PubMed]

Fraga, C.G. and  Oteiza, P.I. Flavanols and procyanidins, rective oxygen species, and NF-κB activation: relevance for disease.  In Free Radical Patophysiology, edited by S. Alvarez, P. Evelson and A. Boveris.  Research Singpost pp. 113-128 (2008). 

Fraga, C.G. and  Oteiza, P.I. Flavanols and NF- κB activation: relevance for inflammation and associated diseases. In Dietary Regulation of Cell Signaling, edited by L. Packer, Z. Dong, E. Cadenas, and Y-J. Surh. CRC Press, pp.137-150 (2008).

Mackenzie, G. G., Adamo, A. M., Decker, N. and Oteiza, P. I. Dimeric procyanidin B2 inhibits constitutively active NF-κB in Hodgkin's lymphoma cells independently of the presence of IκB mutations. Biochemical  Pharmacology. 75:1461-71 (2008). [PubMed]

Mackenzie, G. G., Zago, M.P., Aimo, M. P. and Oteiza, P. I.  Zinc in neuronal biology.  IUBMB Life 59:299-307 (2007). [PubMed]

Mackenzie, G. G. and Oteiza, P. I. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. Journal of Cell Physiology. 210: 246-256 (2007). [PubMed]

Oteiza, P.I. Book review: Molecular interventions in lifestyle-related diseases, edited by M. Hiramatsu, T. Yoshikawa and L. Packer.  American Journal of Clinical Nutrition. 84:670  (2006).

Erlejman, A. G., Fraga C. G. and Oteiza, P. I.  Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage.  Free Radical Biology Medicine  41:1247-1256 (2006). [PubMed]

Mackenzie, G. G., Keen, C. L. and Oteiza, P. I. Microtubules are required for NF-[[kappa]]B nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. Journal of Neurochemistry  99:402-415 (2006). [PubMed]

Mackenzie, G. G. and Oteiza, P. I. Modulation of transcription factor NF-κB in Hodgkin’s lymphoma cell lines: effect of (-)-epicatechin. Free Radical Research. 40:1086-1094 (2006). [PubMed]

Oteiza, P.I. and Verstraeten, S.V.  Interaction of metals with liposome membranes:  Consequences on membrane physical properties. En: Advances in Planar Lipid Bilayers and Liposomes, 4, chapter 3, pp. 79-106. A. Leitmannova Liu, ed. Elsevier (2006). Academic Press publisher. ISSN 1554-4516.

Aimo, L. and Oteiza, P. Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced AP-1 activation. Toxicological Sciences. (2006) 91:184-91. [PubMed]

Mackenzie, G. G., Zago, M. P., Erlejman, A. G., Aimo, L., G., Keen, C. L. and Oteiza, P. I. α-lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-B and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radical Research. (2006) 40:75-84. [PubMed]

Gatica, L., Alvarez, S., Gomez, N., Zago, M. P., Oteiza, P. I., Oliveros, L. and Gimenez, M. S. Vitamin A deficiency induces prooxidant environment and inflammation in rat aorta. Free Radical Research. 39:621-628  (2005). [PubMed]

Zago, M.P, Mackenzie, G. G., Adamo, A. M., Keen, C. L. and Oteiza, P. I. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H2O2.  Antioxidant Redox Signaling.7:1773-1782 (2005). [PubMed]

Fraga, C. G., Oteiza, P. I. and Keen, C. L. Trace elements and human health Molecular Aspects of Medicine.  26:233-234 (2005). [PubMed]

Oteiza, P. I. and Mackenzie, G. G.  Zinc, oxidant-triggered cell signaling, and human health.  Molecular Aspects of Medicine.  26:245-255 (2005). [PubMed]

Verstraeten, S. V., Hammerstone, J. F., Keen C. L., Fraga C. G. and Oteiza, P. I. Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. Journal of Agricultural and Food Chemistry. 53:5041-5048 (2005). [PubMed]

Verstraeten, S. V., Lanoue, L., Keen, C. L. and Oteiza, P. I.  Relevance of polar lipid headgroups on boron-mediated changes in membrane physical properties.  Archives of Biochemistry and Biophysics. 438:103-110 (2005). [PubMed]

Keen, C. L., Holt, R. R., Oteiza, P. I., Fraga, C.G., Schmitz, H. H..  Cocoa antioxidants and cardiovascular health.  American Journal of Clinical Nutrition.  81:298-303 (2005). [PubMed]

Oteiza, P. I., Verstraeten, S. V., Erlejman, A. G., Keen, C. L. and Fraga C. G.  Flavonoid-membrane interactions:  A protective role of flavonoids at the membrane surface?  Clinical and Developmental Immunology.  2:19-25 (2005). [PubMed]

Oteiza, P. I., Mackenzie, G. G. and Verstraeten, S. V.  Metals in neurodegeneration: Erlejman, A., Verstraeten, S. V., Fraga, C. G. and Oteiza, P.I. The interaction of flavonoids with membranes: potential determinant of flavonoid antioxidant effects.  Free Radical Research. 2004 Dec;38(12):1311-20. [PubMed]

Verstraeten SV, Oteiza PI, Fraga CG. Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells. Biol Res. 2004;37(2):293-300. [PubMed]

Oteiza PI, Mackenzie GG, Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr;25(1-2):103-15. Review. [PubMed]

Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan;18(1):167-9. Epub 2003 Nov 20. [PubMed]

Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 1;378(Pt 2):579-87. [PubMed]

Verstraeten, S. V., and Oteiza, P. I. Aluminum-mediated changes on membrane physical properties participate in the inhibition of polyphosphoinositides hydrolysis. Archives of Biochemistry and Biophysics 408:263-271 (2003). [PubMed]

Verstraeten, S. V., Villaverde, M. S. and Oteiza, P. I. Aluminum-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC. Chemistry and Physics of Lipids 122:159-163 (2003) [PubMed]

Actis-Goreta, L., Mackenzie, G. G., Oteiza, P. I. and Fraga, C. G. Polyphenols containing beverages protect cultured cells, human plasma, liposomes, and a pure chemical system, from free radical-mediated oxidation. Alternate Medicine and Emerging Drugs (in press)

Verstraeten, S. V., and Oteiza, P. I. Aluminum-mediated changes on membrane physical properties participate in the inhibition of polyphosphoinositides hydrolysis. Archives of Biochemistry and Biophysics 408:263-271 (2002). [PubMed]

Verstraeten, S. V., Keen, C. L., Schmitz, H. H., Fraga, C. G. and Oteiza, P. I. Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radicals in Biology and Medicine 34: 84-92 (2003) [PubMed]

Mackenzie, G. G., Keen, C. L. and Oteiza, P. I. The zinc status of human neuroblastoma IMR-32 cells influences their susceptibility to iron-induced oxidative stress. Developmental Neuroscience 24: 125-133 (2002). [PubMed]

Erlejman, A. G. and Oteiza P.I. The oxidant defense system in human neuroblastoma IMR-32 cells pre- and post- differentiation to neuronal phenotypes. Neurochemical Research 27: 1491-1498 (2002) [PubMed]

Mackenzie, G. G., Zago, M. P., Keen, C. L. and Oteiza, P. I. Low intracellular zinc impairs the translocation of activated NF-kB to the nuclei in human neuroblastoma IMR-32 cells. Journal of Biological Chemistry 277:34610-34617 (2002). [PubMed]

Fraga, C. G. and Oteiza, P. I. Iron toxicity and antioxidant nutrients. Toxicology 180: 23-32 (2002) [PubMed]

Actis-Goreta, L., Mackenzie, G. G., Oteiza, P. I. and Fraga, C. G. Comparative study of the antioxidant capacity of wines and other plant-derived beverages. Annals of the New York Academy of Sciences 957: 1-5 (2002). [PubMed]

Verstraeten, S. V., Erlejman, A. G., Zago, M. P., and Oteiza, P. I. Aluminum selectively affects membrane physical properties in human neuroblastoma (IMR-32) cells before and after differentiation. Archives of Biochemistry and Biophysics 399: 167-173 (2002) [PubMed]

Oteiza, P. I., Verstraeten, S. V. y Zago, M. P. Modulación de la oxidación lipídica por metales sin capacidad redox. Antioxidantes y calidad de vida 8, 14-18 (2001)

Zago, M. P and Oteiza, P. I. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radicals in Biology and Medicine 31: 266-274 (2001). [PubMed]

Oteiza, P. I., Clegg, M. S. and Keen, C. L. Short-term zinc deficiency affects NF-kB nuclear binding activity in rat testes. Journal of Nutrition 131: 21-26 (2001) [PubMed]

Zago, M. P., Verstraeten, S. V. and Oteiza, P. I. Zinc in the prevention of Fe2+-initiated lipid and protein oxidation. Biological Research 33: 143-150 (2000). [PubMed]

Oteiza, P. I., Clegg, M. S., Zago, M. P. and Keen, C. L. Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radicals in Biology and Medicine 28: 1091-1099 (2000) [PubMed]

Verstraeten, S. V. and Oteiza, P. I. Effects of aluminum and related metals on membrane phase state and hydration. Correlation with lipid oxidation. Archives of Biochemistry and Biophysics 375:340-346 (2000). [PubMed]