Rulan Jiang, Ph.D.

Rulan Jiang

Unit
Assistant Project Scientist, Department of Nutrition

3150E Meyer Hall
Bio

Education

  • Ph.D. Nutritional Biology, University of California, Davis

Research Interests

Dr. Jiang’s research focuses on pediatric nutrition, specifically on absorption and biological roles of bioactive components in human milk, such as lactoferrin and osteopontin. She uses both cell models and animal models to investigate mechanisms by which milk derived bioactive compounds are absorbed and exert their multiple functions. In addition, she is interested in dynamic changes of milk bioactive components throughout lactation in human populations, as well as relationships between the changes and the health outcomes.

Selected Publications

Jiang, R., Prell, C., and Lönnerdal, B. (2018) Milk osteopontin promotes brain development by up-regulating osteopontin in the brain in early life. FASEB J, [Epub ahead of print]

Yang, Z., Jiang, R., Chen, Q., Wang, J., Duan, Y., Pang, X., Jiang, S., Bi, Y., Zhang, H., Lönnerdal, B., Lai, J., and Yin, S. (2018) Concentration of Lactoferrin in Human Milk and Its Variation during Lactation in Different Chinese Populations. Nutrients 10

Jiang, R., and Lönnerdal, B. (2018) Cloning and characterization of the human lactoferrin receptor gene promoter. Biometals 31, 357-368

Jiang, R., Suzuki, Y. A., Du, X., and Lönnerdal, B. (2017) Lactoferrin and the lactoferrin-sophorolipids-assembly can be internalized by dermal fibroblasts and regulate gene expression. Biochem Cell Biol 95, 110-118

Jiang, R., and Lönnerdal, B. (2017) Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. Biochem Cell Biol 95, 99-109

Jiang, R., and Lönnerdal, B. (2016) Biological roles of milk osteopontin. Curr Opin Clin Nutr Metab Care 19, 214-219

Jiang, R., and Lönnerdal, B. (2014) Transcriptomic profiling of intestinal epithelial cells in response to human, bovine and commercial bovine lactoferrins. Biometals 27, 831-841

Jiang, R., Du, X., and Lönnerdal, B. (2014) Comparison of bioactivities of talactoferrin and lactoferrins from human and bovine milk. J Pediatr Gastroenterol Nutr 59, 642-652

Liao, Y., Jiang, R., and Lönnerdal, B. (2012) Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life. Biochem Cell Biol 90, 476-484

Jiang, R., and Lönnerdal, B. (2012) Apo- and holo-lactoferrin stimulate proliferation of mouse crypt cells but through different cellular signaling pathways. Int J Biochem Cell Biol 44, 91-100

Lönnerdal, B., Jiang, R., and Du, X. (2011) Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities. J Pediatr Gastroenterol Nutr 53, 606-614

Jiang, R., Lopez, V., Kelleher, S. L., and Lönnerdal, B. (2011) Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J Cell Physiol 226, 3022-3031