Dr. Engle-Stone's research is in global public health nutrition, with a focus on micronutrient nutrition among women and young children in low-income settings. Research themes include planning, monitoring, and evaluation of food fortification programs; cost-effectiveness and coherence among micronutrient intervention programs, and nutritional assessment.
Academic Senate Faculty & Cooperative Extension
Perinatal period is a critical window of brain development that is featured with robust neuronal growth as well as greater vulnerability to environmental insults. I am interested in evaluating the opportunities and the risks of nutritional factors in modulating neuronal resilience to early-life adverse events (e.g. infection and stress). Domestic piglet is used as translational model of human infants in our studies. We utilize molecular techniques, behavioral tests, disease-challenge models to integrate pathophysiology, neuroimmunology and cognition. In this way, we are able to evaluate how diet induced peripheral “signals” (e.g. metabolites and humoral profiles) exert their function in central nervous system during health and disease.
Dr. Havel is investigating the regulation of energy homeostasis and carbohydrate/lipid metabolism, and the involvement of endocrine systems in the pathophysiology of obesity, diabetes, and cardiovascular disease.
Dr. Oteiza has two primary areas of research. The first is centered on the characterization of the effects of trace mineral deficiencies and trace mineral toxicities on early developmental processes. Dr. Oteiza´s second area of research is focused on the putative health benefits of flavonoids.
Dr. Cherr´s current laboratory focus is on understanding the cellular and physiological mechanisms of reproduction and development over a wide phylogenetic range
Dr. Mackenzie´s research focuses on the role of diet and other lifestyle factors in cancer development and prevention. Current research projects include: 1) Understanding the cellular and molecular mechanisms involved in the link between obesity, inflammation and cancer; 2) Evaluating the role of zinc in pancreatic carcinogenesis; and 3) Investigating the use of select nutraceuticals as potential chemopreventive agents.
Dr. Steinberg’s research program focuses on the physiologic effects of bioactive food components to reduce risk factors for cardiovascular and obesity-related chronic diseases. Human trials and complementary research approaches are used to study metabolic markers of lipid and lipoprotein metabolism, endothelial function, inflammation and metabolic homeostasis; with a goal to examine nutritional phenotypes of individuals responding to intakes of food phytochemicals and characterize metabolic responses which promote health and chronic disease risk reduction.
Dr. Haj's laboratory studies the molecular basis of metabolic diseases, mainly obesity and type 2 diabetes. In particular, we are interested in the role of tyrosine phosphorylation and how dysregulation of this key signaling mechanism contributes to metabolic diseases and their complications. We investigate the role of protein-tyrosine phosphatases and their interacting partners in metabolic homeostasis. This is achieved using a combination of genetic, biochemical, proteomic and pharmacological approaches in various experimental platforms (cells, rodent models of disease and humans).
Dr. Prado's research interests include the effect of nutrition on brain development in children; the effect of nutrition on cognition, mood, and caregiving in mothers; and the cross-cultural and cross-linguistic adaptation and validation of tests of motor, cognitive, and socio-emotional function in children and adults.
Dr. Slupsky's research includes understanding the impact of diet on human health from the perspective of nutrition, the gut microbiome, and host-microbial co-metabolism. She uses a multi-discplinary research approach that integrates metabolomics with clinical measures, global gene expression profiles, as well as microbial community analysis to understand the intimate link between our gut microbiome, metabolism, and health. In addition, she is looking into the implication of food processing, agricultural practices, and plant health status on the nutrient content and sensory aspects of the food we eat. These studies will provide novel insight on health management and food development, and usher us into the era of personalized nutrition.